Last edited by Mezinris
Saturday, August 1, 2020 | History

2 edition of Metabolites and potential metabolites of polycyclic aromatic hydrocarbons (PAH"s). found in the catalog.

Metabolites and potential metabolites of polycyclic aromatic hydrocarbons (PAH"s).

Gerard Anthony O"Kane

Metabolites and potential metabolites of polycyclic aromatic hydrocarbons (PAH"s).

by Gerard Anthony O"Kane

  • 59 Want to read
  • 39 Currently reading

Published .
Written in English


Edition Notes

Thesis (Ph. D.)--The Queen"s University of Belfast, 1987.

The Physical Object
Pagination1 v
ID Numbers
Open LibraryOL19800423M

Rationale: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with adverse effects on the respiratory system. However, the association between internal levels of PAH metabolites and lung function levels remains unclear. Objectives: We investigated the relationships between urinary PAH metabolite concentrations and lung function levels in a .   SULT1A1 also takes part in transformation of hydroxymethyl polycyclic aromatic hydrocarbons, N–hydroxyderivatives of arylamines, allylic alcohols and heterocyclic amines to their reactive intermediates which are able to bind to nucleophilic structures such as DNA and consequently act as mutagens and carcinogens (Glatt et al., ).

Polycyclic aromatic hydrocarbons (PAHs), regarded as a class of hazardous pollutants due to their persistence and toxicity, are ubiquitous in the environment. Much research has been conducted on aerobic microbial degradation of some PAHs and determination of the degradation pathways for which synthesis of metabolic intermediates and metabolites. Polycyclic aromatic hydrocarbons (PAHs) are potent carcinogens and are a primary risk factor for the development of lung and other aerodigestive tract cancers in smokers. The detoxification of PAHs by glucuronidation is well-characterized for the UDP-glycosyltransferase (UGT) 1A, 2A, and 2B subfamilies; however, the role of the UGT3A subfamily in PAH metabolism remains .

Aerobic Utilization of Hydrocarbons, Oils, and Lipids / edited by Fernando Rojo. Show more Show less. In. Springer Nature eReference Series. Handbook of Hydrocarbon and Lipid Microbiology; Handbook of hydrocarbon and lipid microbiology; Edition. 1st ed. Published. This study investigated the mineralization of water-soluble polycyclic aromatic hydrocarbon (PAH) metabolites produced by the soil fungus Cunninghamella elegans. Eleven soil fungi were screened for their ability to metabolize 14C-phenanthrene, 14C-fluoranthene, and 14C-pyrene into water-soluble compounds. Eight fungi produced water-soluble metabolites from all or some of .


Share this book
You might also like
Fodor-Cape Cod,marthas Vnyd/n

Fodor-Cape Cod,marthas Vnyd/n

The drontheim

The drontheim

New Bedford, Ma & Surrounding Towns PM

New Bedford, Ma & Surrounding Towns PM

economics of loyalty-incentive rates in the railroad industry of the United States.

economics of loyalty-incentive rates in the railroad industry of the United States.

American

American

son of learning

son of learning

Oh be joyful!

Oh be joyful!

Light of Liberation

Light of Liberation

thunderstorm.

thunderstorm.

The mediational role of social influence in the perception of exertion

The mediational role of social influence in the perception of exertion

Raising the wind.

Raising the wind.

Statistical indicators of scientific and technical communication (1960-1980).

Statistical indicators of scientific and technical communication (1960-1980).

Graniteware

Graniteware

Experiments in consort of the luctation arising from the affusion of several menstruums upon all sorts of bodies

Experiments in consort of the luctation arising from the affusion of several menstruums upon all sorts of bodies

Metabolites and potential metabolites of polycyclic aromatic hydrocarbons (PAH"s) by Gerard Anthony O"Kane Download PDF EPUB FB2

Metabolic Activation of Polynuclear Aromatic Hydrocarbons deals with the metabolic activation of polynuclear aromatic hydrocarbons and covers topics ranging from the cytotoxic, mutagenic, and carcinogenic effects of arene oxides to the role of secondary metabolites as ultimate carcinogens.

This book shows how the biological transport, bioaccumulation, disposition, and toxicity of polycyclic aromatic hydrocarbons (PAH) in the aquatic environment are influenced by the ability or inability of organisms to metabolize these environmental pollutants.

Written by leading scientists in the fields of PAH metabolism and toxicity in both aquatic and mammalian systems, this book. Urinary polycyclic aromatic hydrocarbon metabolites, peripheral blood mitochondrial DNA copy number, and neurobehavioral function in coke oven workers Author links open overlay panel Juanjuan Du a Baolong Pan a b 1 Xiaomin Cao a Jinyu Li a Jin Yang a Jisheng Nie aAuthor: Juanjuan Du, Baolong Pan, Xiaomin Cao, Jinyu Li, Jin Yang, Jisheng Nie.

UDP-glycosyltransferase 3A (UGT3A) metabolism of polycyclic aromatic hydrocarbons: potential importance in aerodigestive tract tissues. Ana G. Vergara, Christy J.

Watson, Gang Chen, and Philip Lazarus. Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WashingtonAuthor: Ana G. Vergara, Christy J.W. Watson, Gang Chen, Philip Lazarus. 15 hours ago  The seasonal polycyclic aromatic hydrocarbon (PAH) variability was studied in the estuaries of the Partizanskaya River and the Tumen River, the largest transboundary river of the Sea of Japan.

The PAH levels were generally low over the year; however, the PAH concentrations increased according to one of two seasonal trends, which were either an. metabolites being formed. These metabolites include the reactive epoxide BaP 7,8 diol-9,epoxide (BPDE), which is believed to be play a role in the carcinogenicity of BaP.

Following metabolism PAHs are excreted in the urine and/or faeces depending on their molecular weight. This chapter describes the metabolism of PAHs to oxidized and conjugated metabolites by both fish and invertebrates. So far, a wide range of metabolites have been described and a number of studies have alerted for the potential of phenol and quinone derivatives, as well as other reactive intermediates, to exert toxicity in early life stages of fish and reproductive disorders in adults.

polycyclic aromatic compounds. PACs (including hydrocarbons, PAHs) are important due to the continuous input of these compounds in the environment. their bioaccumulation in different links of the food chain. and associated biological effects. PACs. Menichini, B. Bocca, in Encyclopedia of Food Sciences and Nutrition (Second Edition), Introduction.

Polycyclic aromatic hydrocarbons (PAHs) are a large class of organic compounds containing two or more fused aromatic rings.

In particular, the term PAHs refers to compounds containing only carbon and hydrogen atoms (i.e., unsubstituted parent PAHs and their alkyl. 1. Introduction. Polycyclic aromatic hydrocarbons (PAHs) are known as a group of persistent organic pollutants (POPs) (Cui et al., ), including high-molecular-weight PAHs (HMW) with four or more aromatic rings, which are recalcitrant in water, soil sediments and atmosphere (Kim et al., ).With the increase of PAHs concentration in estuarine sediments.

The mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites is also discussed. This book begins with a brief review of the early work on the mechanism of chemical carcinogenesis by polynuclear hydrocarbons, followed by a detailed survey of pertinent literature in the field.

Yeast abundance in the sediments of 13 coastal sites in Massachusetts was quantified, and the potential of yeast isolates to biotransform polycyclic aromatic hydrocarbons (PAHs) was determined. Plate counts of yeasts varied between 10(2) to 10(7) CFU g. The exposure of paving workers to polycyclic aromatic hydrocarbons (PAH) during stone mastic asphalt (SMA) paving and remixing was evaluated.

The effects on the workers' PAH exposure were also evaluated during the use of an industrial by-product, coal fly ash (CFA), instead of limestone as the filler in the. Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer Yesha M.

Patel, 1 Sungshim L. Park, 1 Steven G. Carmella, 2 Viviana Paiano, 2 Natalie Olvera, 2 Daniel O. Stram, 1 Christopher A. Haiman, 1 Loic Le Marchand, 3 and Stephen S.

Explore the latest full-text research PDFs, articles, conference papers, preprints and more on FUNGAL METABOLISM. Find methods information, sources, references or conduct a. A new method for the simultaneous detection of 20 polybrominated diphenyl ethers (PBDEs), 16 polycyclic aromatic hydrocarbons (PAHs), 4 hydroxyl PBDEs (OH-PBDEs) and 10 hydroxyl PAHs (OH-PAHs) in human hair has been developed for the first time.

External target analytes from hair (hair-Ex) were ultrasonicall. We present for the first time experimental evidence on the line-narrowing effect caused by primary alcohols on the spectral features of metabolites of polycyclic aromatic hydrocarbons at 77 K and K.

The investigated metabolites include 1-hydroxypyrene, 2-hydroxyfluorene, 9-hydroxyphenanthrene, 3-hydroxybenzo [ a ]pyrene, 4-hydroxybenzo [ a ]pyrene, 5-hydroxybenzo [ a ]pyrene, B Author: Mohammadreza Chehelamirani, Huiyong Wang, Anthony Santana, Andrés D.

Campiglia. With untreated hamster microsomes, more than 60% of the total metabolites of the hydrocarbon were bay-region diol-epoxides, whereas human liver formed less than 5% of such metabolites.

Addition of 7,8-benzoflavone to the microsomal incubations dramatically stimulated the formation of these metabolites in human (and rabbit) liver microsomes. Polycyclic aromatic hydrocarbons (PAHs) are well-known carcinogens to humans and ecotoxicological effects have been shown in several studies.

However, PAHs can also be oxidized into more water soluble-oxygenated metabolites (Oxy-PAHs). The first purpose of the present project was to (1) assess the effects of a mixture containing three parent PAHs: anthracene.

A polycyclic aromatic hydrocarbon (PAH) is a hydrocarbon—a chemical compound containing only carbon and hydrogen—whose molecule has of multiple aromatic simplest such chemicals are naphthalene, having two aromatic rings, and the three-ring compounds anthracene and terms polyaromatic hydrocarbon or polynuclear aromatic hydrocarbon.

The potential complexity of 1-nitropyrene metabolism, compared to PAH metabolism, is greatly increased by the presence of the nitro group. Extensive studies have shown that nitro-reduction is a key feature of 1-nitropyrene metabolism in Salmonella [email protected]{osti_, title = {Metabolism of polycyclic aromatic hydrocarbons in the aquatic environment}, author = {Varanasi, U}, abstractNote = {The impetus for these studies has come from diverse developments, including increased transport of petroleum across major waterways of the world and consequent concern about accidental spills, reports of epizootics of diseases in .CHAPTER ONE INTRODUCTION Crude oils are composed of mixtures of paraffin, alicylic and aromatic hydrocarbons.

Microbial communities exposed to hydrocarbons become adapted, exhibiting selective enrichment and genetic .